NeuraSignal completes DoD-funded TBI studies at trauma centers

NeuraSignal said Sept. 17 it finished two Department of Defense-funded clinical studies testing whether transcranial Doppler ultrasound and machine analysis can help estimate intracranial pressure and detect brain-injury-related abnormalities. The studies enrolled 618 participants across military and academic trauma centers and add data for a non-invasive approach to traumatic brain injury care.

Why it matters: - Traumatic brain injury often requires invasive monitoring or CT-based assessment. - NeuraSignal’s studies test whether transcranial Doppler ultrasound, paired with computer analysis, could give clinicians additional non-invasive information about intracranial pressure and brain injury. - The work adds clinical evidence for a technology that could expand access to neurovascular assessment in emergency and trauma settings.

What happened: - NeuraSignal announced the completion of two clinical studies funded through Department of Defense grants. - The studies enrolled 618 participants in total. - One study was completed in March 2025. The second was completed in March 2026. - The company said the research examined whether brain blood-flow velocity measurements analyzed with NeuraSignal technology could estimate pressure inside the skull or identify abnormalities linked to traumatic brain injury.

The details: - The first study, Prospective non-invasive study of Cerebral Blood Flow Velocity (CBFV) Morphology for Quantification of Intracranial Pressure (ICP), enrolled 248 participants. - That study ran across Brooke Army Medical Center and Westchester Medical Center. - Researchers compared TCD-derived measurements with readings from standard invasive intracranial pressure monitors. - NeuraSignal shared study data with Emory University under a data-sharing agreement to support algorithm development. - The first study was translated into a publication. - The second study, Precision Intracranial Bleed Triage and Monitoring, enrolled 370 patients. - That study took place at Brooke Army Medical Center and UT Health Science Center San Antonio in San Antonio, Texas. - Researchers compared TCD measurements with CT scans. - The analysis looked at whether changes in blood-flow velocity could distinguish patients with bleeding or other CT-visible injuries from patients without those findings. - Data analysis on the second study is ongoing. - NeuraSignal CEO Robert Hamilton said the studies show the company’s commitment to investing in research, technology and clinical evidence to expand TCD’s capabilities.

Between the lines: - The studies do not prove TCD can replace current standards of care. - The design instead focuses on where non-invasive blood-flow measurements may add value and where more validation is still needed. - The mix of military and civilian trauma centers suggests the company is targeting settings where rapid brain-injury triage matters most.

What's next: - NeuraSignal will continue analyzing the second study’s data. - Further validation will likely determine how far TCD-based methods can go in routine traumatic brain injury assessment. - The company said the research is helping define where the technology may contribute to care. - For more information, visit the company's announcement.

The bottom line: - NeuraSignal has finished a two-study DoD-backed push to test whether non-invasive ultrasound and machine learning can help assess traumatic brain injury, but more analysis and validation are still ahead.